Convinced that his wayward brother LINCOLN BURROWS (Dominic Purcell) was wrongly convicted of the sensational murder of the Vice President’s brother, which landed him on Fox River State Penitentiary’s death row, a desperate MICHAEL SCOFIELD (Wentworth Miller) attempted a daring bank robbery in order to get himself incarcerated in Fox River with Lincoln. Michael, an engineer with access to the prison’s structural design, then masterminded an elaborate plan to free Lincoln by pulling off the ultimate PRISON BREAK.

Aided by an intricate tattoo of the prison’s blueprints covering his upper body, Michael aligned himself with his lovelorn cellmate FERNANDO SUCRE (Amaury Nolasco), former mob boss JOHN ABRUZZI (Peter Stormare), homicidal pedophile “T-BAG” (Robert Knepper), the well-connected “C-NOTE” (Rockmond Dunbar) and CHARLES WESTMORELAND (Muse Watson), a man Michael believed to be the infamous skyjacker D.B. Cooper. On the outside, Michael’s only ally was his defense attorney and Lincoln’s former girlfriend VERONICA DONOVAN (Robin Tunney), who protected Lincoln’s targeted son LJ (Marshall Allman). Veronica’s quest for the truth led straight to the White House, Secret Service Agent PAUL KELLERMAN (Paul Adelstein) and the power-hungry Vice President, CAROLINE REYNOLDS (Patricia Wettig), whose brother, in secret, is very much alive.

Overcoming many setbacks, the brothers and six other inmates ultimately escaped from Fox River. The prison break had its consequences, however – Michael was forced to betray his father figure, Warden HENRY POPE (Stacy Keach); prison doctor SARA TANCREDI (Sarah Wayne Callies), who was instrumental in the escape plan and had romantic feelings for Michael, relapsed with drugs and overdosed; and Westmoreland died of injuries sustained in the escape, but not before revealing that he was indeed D.B. Cooper – and providing a clue to where he had hidden over $5 million in cash.

Outside the prison walls, the escape truly begins as the convicts race for their lives – and the hidden cash –while trying to avoid capture by the authorities. The pursuers are led by vengeful prison guard Captain BRAD BELLICK (Wade Williams), who, driven by a personal vendetta, will stop at nothing until the escapees are captured or killed.